Quality Of Life In Women During The Menopausal Transition
Keywords:
menopausal transition; quality of life; climacteric syndrome; magnesium deficiency; pyridoxine; non-hormonal therapy; UzbekistanAbstract
The menopausal transition is associated with hormonal fluctuations that lead to vasomotor, psychological, and somatic symptoms, significantly impairing quality of life in women. Assessment of quality of life has become a key indicator for evaluating the severity of climacteric syndrome and the effectiveness of therapeutic interventions. Objective: To assess quality of life in peri- and postmenopausal women and to evaluate the effectiveness of a non-hormonal therapy based on a fixed combination of magnesium citrate and pyridoxine.
Materials and Methods: A large multicenter clinical study was conducted in the Republic of Uzbekistan and included over 11,000 participants. A subgroup of 3,808 women with climacteric syndrome was analyzed, including patients receiving and not receiving menopausal hormone therapy. Quality of life indicators and serum magnesium levels were assessed before and after four weeks of therapy with magnesium citrate combined with pyridoxine. Results: A high prevalence of magnesium deficiency was identified among peri- and postmenopausal women (55.0% in patients receiving menopausal hormone therapy and 63.9% in those not receiving hormone therapy). Four-week administration of magnesium citrate with pyridoxine led to a significant increase in serum magnesium levels, a reduction in the severity of climacteric symptoms, and a marked improvement in quality of life parameters. The treatment demonstrated a favorable safety and tolerability profile.
Conclusion: The menopausal transition is accompanied by a significant decline in quality of life. Non-hormonal therapy with a fixed combination of magnesium citrate and pyridoxine is an effective and safe approach for reducing climacteric symptoms and improving quality of life in peri- and postmenopausal women. Clinical data obtained in Uzbekistan support the use of this therapy as part of an individualized management strategy.
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